by C. A.
RESEARCH QUESTION: What role do genes
have in the development of alcoholism?
Introduction
Matt McGue started his longitudinal Twin Studies in the 1990s and they indicated that genetics factors exerted a substantial influence on alcoholism risk in males but not females. His recent work has shown that the age at which an individual first tries alcohol is predictive of a wide range of adult behavioral problems, including alcoholism, drug abuse, academic underachievement, and antisocial personality disorder. He also showed so far that the age at first drink is familial and, at least in males, heritable. Based on his findings he is hypothesizing that an early age at first drink is an indicator of vulnerability to disinhibitory behavior and psychopathology and he is continuing to explore in the Minnesota Twin Family study. (McGue)
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Ebsco Host:
OPIOIDS -- Physiological effect
DRINKING of alcoholic beverages
GENETIC code
MENTAL illness -- Genetic aspects
EVOKED potentials (Electrophysiology);
DUAL diagnosis; MENTAL illness
PLS Online Catalog:
Alcoholism -- Genetic aspects
Brain -- Effect of drugs on
Alcohol -- Physiological effect
Alcoholism -- Treatment
Alcohol, Ethyl -- adverse effects
Alcohol, Ethyl -- pharmacology
Alcoholism -- genetics.
Brain -- drug effects.
Proquest Newspapers Database
Genetics
Alcoholism
Biomedical Research
Research Society on Alcoholism
WEBLIOGRAPHY
Blum, Kenneth. Alcohol and the Addictive Brain: New Hope for Alcoholics from Biogenetic Research. New York: Free Press, 1991.
Gene Study Probes Link of Alcoholism to Depression. Alcohol and Drug Abuse Weekly. 7 May 2001:1. Health Source: Nursing/Academic Edition. Ebsco Host. 5 May 2002. http://search.epnet.com/direct.asp?AN=4431933&db=hch&
Gianoulakis, Christina. Influence of the endogenous opioid system on high Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. Journal of Psychiatry and Neuroscience, Sep.2001:304+. Nursing/Academic Edition. Ebsco Host. 1 May 2002. <http://search.epnet.com/direct.asp?AN=5290395&db=hch&>
Jang, Kerry L. et al. Intra- and extra-familiar influences
on alcohol and drug misuse: a
Madden, Pamela A. F. et al. Smoking and the Genetic
Contribution to Alcohol-
McGue, Matt. A Behavioral-Genetic Perspective on Children of Alcoholics. Alcohol Health and Research World. 1997:210+. Academic Search Elite. Ebsco Host. 5 May 2002. http://search.epnet.com/direct.asp?AN=1136497&db=afh&
Matt McGue is a Professor at the University of Minnesota. He teaches:
1 Behavioral Genetics
2 Readings in Individual Differences and Behavioral Genetics
3 Statistics for the Behavioral Sciences
He is a behavioral geneticist with two primary areas of research. The first concerns the development of substance disorders from adolescence to adulthood. Twin studies that he completed in the early 1990s indicated that genetic factors exerted a substantial influence on alcohol risk in males but not females. So in 1990, he started the Minnesota Twin Family Study, a longitudinal investigation of 1400 families, each consisting of a pair of like sex adolescent twins and their parents.
National Council on Alcoholism and Drug Dependence.
14 March 2002. National Council on Alcoholism and Drug Dependence,
Inc. 8 May 2002. http://www.ncadd.org/.
National Institute on Alcohol Abuse and Alcoholism. May 2002, National Institutes of Health. 2 May 2002. http://www.niaaa.nih.gov/
The
NIAAA supports and conducts biomedical and behavioral research on the
causes consequences, treatment, and prevention of alcoholism
and alcohol-related problems. They also provide leadership in the
national effort to reduce the severe and often fatal consequences of
these problems. They disseminate their research findings to health
care providers, researchers, policymakers and the public.
Slutske, Wendy S. et al. Personality and the
Genetic Risk for Alcohol Dependence.
Journal of Abnormal Psychology. Feb. 2002:124. Academic Search
Elite. Ebsco Host. 5 May 2002. http://search.epnet.com/direct.asp?AN=6377326&db=afh&
Wendy Slutske is a Professor at the University of Missouri. Her education includes:
B.S. in Psychology, University of Wisconsin, Madison 1986
Internship in Clinical Pschology, Indiana School of Medicine 1991-92
Ph.D in Clinical Psychology, University of Minnesota 1993
NIMH Postdoctoral Fellow in Psychiatric Epidemiology and Biostatistics 1993-96
Wendy Slutskes research focuses primarily on the etiology and classification of externalizing psychopathology. She uses mainly behavioral genetic and epidemiologic methods to examine genetic and environmental risk and protective factors for externalizing psychopathology. The research is funded by grants from the National Institute on Alcohol Abuse and Alcoholism and the National Institute of Mental Health.
Her home page was last updated on July 14, 2001. Her work has been published in many professional journals such as The Journal of Consulting and Clinical Psychology and the Archives of General Psychiatry.
The Journal of Abnormal Psychology is a scholarly journal; it is published four times a year and is peer reviewed. It is published by the American Psychological Association in Washington, D. C. and was first published in August, 1990. They include articles on basic research and theory in the broad field of abnormal behavior. Each article represents an addition to knowledge and understanding of abnormal behavior either in etiology, description or change.
Weiss, Rick.
Discovery May be Brewing in Search for Genetic Link to
Alcoholism The
Rick
Weiss is a science and medical reporter for the Washington Post. He
came to the Posts Health section in 1993 and moved to the
national desk in January 1996, where he covers genetics, molecular
biology and other topics in the life sciences. Weiss is 51 years old
and he earned a B.S. in biology from Cornell University in 1974. For
ten years, he worked as a licensed medical technologist in hospital
laboratories, specializing in microbiology, serology and blood
banking. In 1983 he entered the Graduate School of Journalism at the
University of California, Berkeley, where he earned a Masters in
Journalism. He has also worked for Health magazine and Science News
magazine and Memorial Sloan-Kettering Cancer Center. This particular
article would be valuable for historic material related to the
Collaborative Study on Genetics, which was started in 1989 by the
NIAAA, a division of the National Institutes of Health. http://www.santafe.edu/~johnson/sciwrite.weiss.html.
The Washington Post newspaper
is an operation division of the Washington Post Company. The Company
is a diversified media company whose principal operations include
newspaper and magazine publishing, television broadcasting, cable
television services, test preparation and educational and career
services. Company headquarters are in Washington, D.C.
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last revised: 5-7-02 by Eric Brenner, Skyline College, San Bruno,
CA
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